Parkinson’s patients and others suffering debilitating tremors could be cured of their shaking using a new ultrasound machine which targets their brain cellsDoctors at Imperial College Healthcare NHS Trust have treated the first patients using the new technique which avoids the need for invasive brain surgery.
Squalamine, a chemical compound found in dogfish sharks, has the potential to reduce the formation of toxic proteins related to the development of Parkinson’s disease, new research suggests
Published in the Proceedings of the National Academy of Sciences, the study reveals that squalamine halted the buildup and toxicity of the protein alpha-synuclein (α-synuclein) in roundworm models of Parkinson’s disease and human neuronal cells.
Read more http://www.telegraph.co.uk/science/2017/01/16/dogfish-shark-extract-could-help-treat-parkinsons-disease-scientists/
A new investigational drug originally developed for type 2 diabetes is being readied for human clinical trials in search of the world’s first treatment to impede the progression of Parkinson’s disease, following publication of research findings today in the journal Science Translational Medicine. More
A drug initially designed to treat diabetes may be a breakthrough treatment for Parkinson’s disease. After decades of disappointment, could MSDC-0160 be the drug researchers have been searching for? More
This post is about experimental drugs and treatments, Under absolutely no circumstances should anyone reading this consider it medical advice. These are novel results that need to be replicated and verified before being considered gospel. Before considering or attempting any change in your treatment regime, please consult with your doctor or neurologist.
The natural sweetener mannitol, a common component of sugar-free gums and candies, may hold potential for Parkinson’s disease (PD) according to a study, funded in part by the Parkinson’s Disease Foundation, in the June 14, 2013 issue of The Journal of Biological Chemistry. In this initial study, the compound not only improved PD-like symptoms in fruit flies, but also reduced harmful levels of alpha-synuclein (the hallmark of PD) in the brains of fruit flies and mice.
The Israeli scientists were interested in the ability of Mannitol to inhibit the formation of alpha synuclein aggregates (clumps of the protein that is associated with Parkinson’s disease). Chemicals similar to Mannitol have exhibited protein destabilizing properties, so it was an interesting idea to test.
The researchers used different concentrations of mannitol and added it to a solution of alpha-synuclein. They left this concoction shaking for 6 days (at 37°C) and then assessed the levels of aggregation. Curiously the low levels of Mannitol had the strongest inhibitory effect, while the higher concentrations had no effect. The researchers repeated the experiments and found similar results.
Given this success, they turned their attention to an animal model of alpha synuclein: a genetically engineered fly that produces a lot of alpha synuclein. They found that Mannitol treated flies had significantly less alpha synuclein aggregation in their brain than untreated flies. This study was then repeated in genetically engineered mice (that produce too much alpha synuclein) and guess what? They found the same results.
These results led the scientists to suggest that “mannitol administration in combination with other drugs could be a promising new approach for treating PD and other brain-related diseases such as Alzheimer disease”.
A warning regarding Mannitol
Before you rush out and start loading up on Mannitol there are a few things you should know about it.
It is used medically, usually to treat increased pressure within the skull.
It should not be abused, however, as it can have an osmotic effect (in particular, attracting water from the intestinal wall). Consumed in excess, it will cause diarrhea, abdominal pain, and excessive gas.
In addition to intestinal problems, Mannitol has also been associated with worsening heart failure, electrolyte abnormalities, or low blood volume. We also do not know what effect it may have on absorption of L-dopa and other Parkinson’s disease medications.
New drug research shows promising results in mice bred to develop the motor symptoms of Parkinson’s disease. A team in Finland finds that blocking an enzyme called prolyl oligopeptidase clears the mice’s brains of an accumulated protein that is a hallmark of Parkinson’s disease, halts further brain damage, and corrects movement impairment.
Haiyan Zhang, Innovation Director at Microsoft Research Cambridge, has taken part in the BBC’s The Big Life Fix challenge which asks young technologists to use their skills to help others.
Her task was to find a way to help 29-year-old Emma Lawton, who is a graphics designer, to improve her writing and drawing skills after this was negatively impacted by her Parkinson’s Disease diagnosed three years ago.
A new project for the early detection of Parkinson’s disease with strongly magnetized xenon gas has been initiated at FMP. The team led by physicist Leif Schröder has received a three-year grant from the Michael J. Fox Foundation for Parkinson’s Research. Read more
Results from Phase 1, Phase 2a and preclinical studies of CVT-301, an inhaled form of levodopa, have been featured in the current edition of Science Translational Medicine. Acorda Therapeutics, Inc. (NASDAQ: ACOR) is developing CVT-301 for the treatment of OFF periods in people with Parkinson’s disease (PD).
Caffeine-based compounds show promise against Parkinson’s disease
Two caffeine-based chemical compounds have been developed that show promise in preventing the ravages of Parkinson’s disease. Parkinson’s disease attacks the nervous system, causing uncontrolled shakes, muscle stiffness, and slow, imprecise movement, chiefly in middle-aged and elderly people. It is caused by the loss of brain cells (neurons) that produce dopamine, an essential neurotransmitter that allows neurons to “talk” to each other.
PEDALING FOR PARKINSON’S Pedaling a bicycle may change the life of someone with Parkinson’s disease. Research conducted at the Cleveland Clinic showed a 35% reduction in symptoms by the simple act of pedaling a bicycle
The mission of Pedaling for Parkinson’s is: To improve the quality of life of Parkinson’s disease patients and their caregivers. To educate patients, caregivers, and the general public about the benefits of maintaining an active